Seeking Advice for Building a Computer for Qiime2

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I would go for at least 16 GB of RAM and SSD from 256 GB. The higher you can get the better it will be. With CPU I would go for at least 6 if you want to run something in multithreaded mode (with a cost of RAM).

RAM and SSD capacity - You can easily run out of RAM or storage for temporary files while running some heavy tasks or large datasets. But 30 samples should be acceptable.

I guess it either can handle it or not, rather than the quality of the analyses will be dependent on the machine specs,

It depends on the most important component of any bioinformatical analysis - the one between the chair and the monitor. If you don't quite know yet what to do, it can take months, or a couple of days/weeks if you are experienced in the field and experimental design is simple.

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