qiime demux emp-paired error with 4 input files: R1 R2 I1 I2, Barcode header lines do not contain description fields but sequence header lines do.

Thank you for taking the time to look at this. I got it working but had already started on my solution before your most recent reply.
I ended up adding this ending to all of my concatenated barcode fastq records: 3:N:0:1. This is very similar to what you suggested (add 1:N:0:1 to the barcodes header line so it matches the R1 reads).

I saw a reference to barcode R3 files in this post https://forum.qiime2.org/t/clarify-on-demux-emp-paired/5565 which mentioned

(barcodes should be in R3 ). It will use the order of R3 to work out which sequences from R1 and R2 belongs to which samples.

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