Phylogenetic distance and differences in microbiome

Hi all,

Is it possible to relate the phylogenetic distance in a phylogenetic tree with the differences that may exist between the microbiome of each of the tree’s components? If so, what programs could you use for this? QIIME 2? my idea is to build a heat map or something similar, but I do not know if it is possible to do it with QIIME 2 or a similar program for metagenomics.

Welcome @arturo!

It sounds like you are describing UniFrac distance, available in QIIME 2’s q2-diversity plugin. See the QIIME 2 tutorials for some more description of when and how this method is used in a typical workflow.

Check that out and let us know if that’s what you are looking for.