Is there a pre-trained QIIME 2 classifier with full-length 16S (.qza)?

:rofl: Hahaha, I totally understand! Cheers! :hot_beverage:

Yeah, I consensus vsearch can use a lot of resources.

I often try to find a small computer with a fast processor with ~32-64 GB RAM to train my classifiers. I am able to train a full SILVA DB on my M1 Max Macbook Pro in less than a few hours. The HPC that I have access too, has very slow and old CPUs... thus, it usually takes a couple days for that to perform the same task. :frowning:

Have you tried the GTDB database? You can use RESCRIPt to download the 226 version and see how that performs.

-Cheers!

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