How to decide when to cluster after denoising?

Hello, all! Greetings of the day.
I am joining the workshop as a free attendee via YouTube Live stream for past two days. Thank you for such a great and comprehensive guidance and tutorials & lectures. It would be a great help for me!
I have a query in context of Denoising and Clustering steps discussed in the previous day of the workshop. I want to know more about how can we decide whether or not to go for Clustering steps after denoising? What factors or requirements should affect our decision making? The example of ITS sequences was helpful but I would like more clarity on this. Please help.

P.S.: If this is not the appropriate platform to clear doubts and ask questions for free attendees, please guide me to where I can ask this. That would help.

Deep regards.
Thank you very much.