Frequent Questions and "Best of the QIIME 2 Forum"

[Francisco (Francisco Cárdenas)]

DADA2 is not the only way to merge and clean sequences, i think this should be here:

DADA2 vs Deblur

Hi @hulfred, I don’t believe an independent benchmark has been performed yet to help inform a decision here. The algorithms do have similarities, and key differences. And to be transparent, I am a developer with Deblur. At a high level, DADA2 uses PHRED scores to inform an error model. Deblur deviates from this and instead uses a static error model. As a result, DADA2 is potentially better able to accommodate run specific errors. The benefit of a static error model though is that it potentiall…