Relative differential analysis for taxonomy

Hello,
I have gut microbiome dataset from a clinical trail. It was a pre-post trial involving a treatment group and a placebo group.
I am trying to use deicode to find the change in the taxonomy. However, I wish to find the significant changes in the taxonomy for the treatment group relative to the changes in the placebo group. [Similar to a beta diversity analysis].
I am confused how do I proceed using DEICODE? Can songbird be useful in it?

Here is how the clinical trail looks like[check the pic] :