qiime itsxpress trim-single fatal error: file too small

Well, based on my experience with other issues it seems like :

If you're running out of storage maybe your directory where Qiime is installed is full, so itsxpress (which is installed whithin Qiime environment) can't create tmp files.
Check how full are your file systems with df -h
Also, have a look here and see if that's make sense for your case: No space left on device classifier TMPDIR

If at least itsxpress start running, check this line from the log in the screen:
2019-12-10 16:26:58,419: INFO Temporary directory is: /any/path/itsxpress_jnvs8k7r
and see if /any/path/ points to a place in a full disk. That is the default diretory Qiime uses for storing tmp files.

I have got into this issue and in my case the /home/ was full because that's were Conda-qiime is installed. I then set the TMP directory to a directory placed in a larger disk and it worked.
Cheers