@Jee-Woong_Choi, you might checkout this thread for more discussion about differential abundance analyses in QIIME 2. Improving our tool kit for differential abundance work is on our list of things to get done this year, though not sure exactly when that will happen 
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I wish I had more helpful input here, but I am not a statistician, maybe @mortonjt would have some better suggestions? I think at this point we just have ANCOM and q2-gneiss, as documented in our plugin workflow page.