Picrust2 accuracy / internal validity

I am developing a tool that takes as input the presence/absence of KO pathways predicted by picrust2. Since the errors made in prediction will propagate through to the final result I have been looking for a summary of the internal validity of Picrust2’s predictions on a per-pathway basis, i.e. leave-one-out cross validation on the database used in the manuscript. Has this analysis been done and is it available somewhere?

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The code for that manuscript appears to be in this GitHub repo:

I have not tested this myself, but would be interested in your experience with it (and your new tool!)

Colin

P.S. Welcome to the forums! :wave:

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