Hi @Alexandra_Bastkowska! Could you provide a bit more detail? We aren't quite sure what it is you are looking to do (sorry!). Have you performed the kind of QC you are thinking of before, with other tools? If so, could you let us know which tools, and please summarize the workflow. The only other thing that comes to mind is this recent post on filtering out blanks, but it doesn't seem to quite line up with what you are describing. Thanks so much! 