how to compare OTU frequencies across samples using Qiime2

Dears,
I have 4 different sample groups of 16S rRNA Illumina sequencing results. Is there any plugin or tool in Qiime2 that can compare OTU frequencies in sample groups and to know whether or not there is any statistically significant differences between OTU abundance in the sample groups?
Thanks.

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The following links might be useful to you;

Differential abundance analysis with gneiss https://docs.qiime2.org/2019.10/tutorials/gneiss/

Differential abundance testing with ANCOM https://docs.qiime2.org/2019.10/tutorials/moving-pictures/#differential-abundance-testing-with-ancom

Good luck!

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