In my experience, Dada2 was running even 2-3 days (8GB Ram) in a virtual Machine (qiime2 v.11).
The same dataset was running for about 4-5 ours on the same PC in Dada2 using R instead of VM.
VM is generally much slower.
However the current (12) version of Q2 has propably better performance.
I would recommend using dada2 protocol on windows in RStudio, and then move results to qiime2 and finish experiment.
Here is a solution: