Thanks for your reply,
In summary, DADA2 create an unusually large table because of unremoved artifacts and low-quality base, resulting in the process suspension.
I will try the following methods to resolve the problem
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Use q2-cutadapt and a reliable list to remove potential artifacts
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Perform quality filtering and trimming before executing DADA2
I will update this post, if I find something important.
Thank you for your time and attention.
potatoo