Hi @dvdharkin ,
Runtime for ancom, like many things, really depends on much more than hardware specs — it is really quite difficult to predict.
As @andrewsanchez already pointed out, ancom can be quite computationally intensive if you have many features and/or samples. Issues with runtime have been reported a lot on this forum, so you could search the archives for different ways to address this, e.g., the advice in this post still stands:
Other than that, the best system spec for using ancom is a bit of patience 
Good luck!