# Will discrete false-discovery rate be integrated to ANCOM?

**URL:** https://forum.qiime2.org/t/will-discrete-false-discovery-rate-be-integrated-to-ancom/1993
**Category:** User Support
**Tags:** dsfdr
**Created:** [November 27, 2017, 10:34pm UTC](https://forum.qiime2.org/t/will-discrete-false-discovery-rate-be-integrated-to-ancom/1993 "2017-11-27T22:34:08Z")
**Posts on this page:** 7
**Page:** 1

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### Author: ![yanxianl](https://forum.qiime2.org/user_avatar/forum.qiime2.org/yanxianl/32/2039_2.png) [@yanxianl](https://forum.qiime2.org/u/yanxianl)
#### Post date: [November 27, 2017, 10:34pm UTC](https://forum.qiime2.org/t/will-discrete-false-discovery-rate-be-integrated-to-ancom/1993/1 "2017-11-27T22:34:09Z")

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Hello,

A new paper introducing the discrete false-discovery rate just published. Will it be used to replace the FDR in the ANCOM in future release, soon?

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### Author: ![jjmmii](https://forum.qiime2.org/letter_avatar_proxy/v4/letter/j/f475e1/32.png) [@jjmmii](https://forum.qiime2.org/u/jjmmii)
#### Post date: [November 28, 2017, 9:47am UTC](https://forum.qiime2.org/t/will-discrete-false-discovery-rate-be-integrated-to-ancom/1993/2 "2017-11-28T09:47:23Z")

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Hey @yanxianl, I think it's already implemented [here](https://github.com/serenejiang/q2_dsfdr)!  
I found this QIIME 2 plugin in [this](https://forum.qiime2.org/t/specify-w-cutoff-for-anacom/1844/12) thread.

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### Author: ![yanxianl](https://forum.qiime2.org/user_avatar/forum.qiime2.org/yanxianl/32/2039_2.png) [@yanxianl](https://forum.qiime2.org/u/yanxianl)
#### Post date: [November 28, 2017, 10:30am UTC](https://forum.qiime2.org/t/will-discrete-false-discovery-rate-be-integrated-to-ancom/1993/3 "2017-11-28T10:30:32Z")

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Woo, it's already available.  
Thanks!

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### Author: ![yanxianl](https://forum.qiime2.org/user_avatar/forum.qiime2.org/yanxianl/32/2039_2.png) [@yanxianl](https://forum.qiime2.org/u/yanxianl)
#### Post date: [December 12, 2017, 9:01pm UTC](https://forum.qiime2.org/t/will-discrete-false-discovery-rate-be-integrated-to-ancom/1993/4 "2017-12-12T21:01:32Z")

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Hello @jjmmii,

I've successfully installed the q2-dsfdr plugin in qiime 2 2017.11 and checked its usage. It seems that q2-dsfdr is a standalone plugin that can be used for the multiple comparison correction of various statistical analysis. I want to use it in the ancom analysis such that a somewhat arbitary filtering of low-prevalence features (25%) is avoid, but I don't know how to implement dsfdr in the ancom analysis. No tutorials have been published in the qiime2 documentation or forum yet. Any suggestions on how to apply dsfdr to the ancom in qiime2?

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### Author: ![jjmmii](https://forum.qiime2.org/letter_avatar_proxy/v4/letter/j/f475e1/32.png) [@jjmmii](https://forum.qiime2.org/u/jjmmii)
#### Post date: [December 13, 2017, 3:46am UTC](https://forum.qiime2.org/t/will-discrete-false-discovery-rate-be-integrated-to-ancom/1993/5 "2017-12-13T03:46:01Z")

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Sorry I'm not familiar with this, please wait for others to respond.

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### Author: ![mortonjt](https://forum.qiime2.org/user_avatar/forum.qiime2.org/mortonjt/32/3488_2.png) [@mortonjt](https://forum.qiime2.org/u/mortonjt)
#### Post date: [December 13, 2017, 8:04pm UTC](https://forum.qiime2.org/t/will-discrete-false-discovery-rate-be-integrated-to-ancom/1993/11 "2017-12-13T20:04:13Z")

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@yanxianl there is currently no way to run dsfdr with ANCOM without modifying the source code for ANCOM. The code change itself would be small (would need to change this [line](https://github.com/qiime2/q2-composition/blob/master/q2_composition/_ancom.py#L58)) Pull requests are welcome.

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### Author: ![system](https://forum-qiime2-org.s3.dualstack.us-west-2.amazonaws.com/original/3X/2/1/21af5fe23cb6f4579467c66a9ed94e55274ca7bd.svg) [@system](https://forum.qiime2.org/u/system)
#### Post date: [January 14, 2018, 2:05am UTC](https://forum.qiime2.org/t/will-discrete-false-discovery-rate-be-integrated-to-ancom/1993/13 "2018-01-14T02:05:35Z")

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