Hello Kathryn,
Welcome to the Qiime 2 forums! :qiime2:
Yes. The main method is to use feature-table filter-samples to make two new tables that just have nasal samples and gut samples as shown here, then use the normal group-signifance plugins on each of these two tables.
Or try using qiime diversity adonis to compliment the results of beta-group-significance.
The adonis test lets you you can partition out sources of variance in order, so that you don't have to break them into seperate tables. For example, you could use the formula
--p-formula "tissue + treatment"
to show the variation explained by tissue, then show the variation explained by treatment after controlling for tissue.
Let me know if that's helped answer your question.
Colin