Hi @qamrq25,
It'd help if you can define to us what you mean by the term:
This can mean many different things. Is there a reference from a paper, or other documentation, that you can share with us? This will help us better understand what type of analysis you are trying to perform. I assume you want a comparison between samples (i.e. beta diversity of microbial communities), like Bray Curtis (dissimilarity matrix), UniFrac,... Something else?
Yes. There are many beta-diveristy metrics to choose from, some of which are available in QIIME 2. I'd recommend going through the tutorials and see if what you need is there. Particularly the diversity analysis overview.
-Mike