How to train a classifier for paired end reads from QIAseq 16S/ITS Panel data using QIIME2 feature classifier

You could make one classifier for each primer pair. At the very least, you should make separate classifiers for ITS and 16S, but you could also use a full-length 16S classifier (e.g., one of the pre-trained classifiers on the QIIME 2 website) to classify all of the 16S domains simultaneously.

Judging from the Qiagen website, it appears that they split the different primer pairs into separate datasets and classify these separately.

So I recommend you do the same. If primers are present in your reads, you can use q2-cutadapt to split up your sequences into groups prior to denoising. If not, denoise everything together and use qiime quality-control exclude-seqs to filter out individual amplicon sites by aligning against reference sequences trimmed to the same amplicon region.

I hope that helps!