Hello @ucassee,
This is a great question, and I'm not sure there is an official solution. But have to try because we don't want to lose have the reads!
I had a great discussion about this exact issue, and we discussed the options and what to try first. Let me know if you find this thread helpful: Dealing with non-oriented amplicon libraries
Let me know if you are able to try any of the suggestions in that thread, especially close-ref OTU picking.
Colin