I have a very special problem. I’ve got data only about the abundance of specific phyla in a patient cohort. That means that I know how many of each Phyla a patient has, like:
Patient 1: 10 of phyla 1, 21 of phyla 2, 300 of phyla 3, … etc.
Patient 2: 15 of pyhla 1, 26 of phyla 2, 365 of phyla 3, … etc.
However I want to go on with microbiome analysis but therefore I need OTUs. However, OTUs are used to classify bacteria at the genus level, but now I have the data on phyla level and I have no 16S sequencing data. How can I create an OTU only by having the phyla abundance? Is is possible?
Do I really need OTUs? Can I analyse alpha-/beta-diversity without OTUs?
I would be really glad about any help!