# Denoising paired ends with DADA2 **URL:** https://forum.qiime2.org/t/denoising-paired-ends-with-dada2/8447 **Category:** Technical Support **Created:** [February 20, 2019, 3:57am UTC](https://forum.qiime2.org/t/denoising-paired-ends-with-dada2/8447 "2019-02-20T03:57:16Z") **Posts on this page:** 1 **Showing post:** 17
### Author: ![thermokarst](https://forum.qiime2.org/letter_avatar_proxy/v4/letter/t/8e7dd6/32.png) [@thermokarst](https://forum.qiime2.org/u/thermokarst) #### Post date: [March 20, 2019, 10:00pm UTC](https://forum.qiime2.org/t/denoising-paired-ends-with-dada2/8447/17 "2019-03-20T22:00:41Z")
Hey there @Imee19 --- let's start over. The error message you reported [above](https://forum.qiime2.org/t/denoising-paired-ends-with-dada2/8447/10) appears to be the exact same error message discussed on the DADA2 [issue tracker](https://github.com/benjjneb/dada2/issues/614). The issue on the DADA2 issue tracker mentions that one way that this error crops up is _when all the reads in the input are unique_ --- the error model has nothing to work with, since there are no repeated reads. It is possible that you have run into this situation. Reading more of the issue tracker, one possible solution is to proceed with only your forward reads. Outside of DADA2 - other options to try are OTU clustering or deblur. Hope that helps! :qiime2: --- _[View the full topic](https://forum.qiime2.org/t/denoising-paired-ends-with-dada2/8447)._