# ANCOMBC - Clarifying Questions

**URL:** https://forum.qiime2.org/t/ancombc-clarifying-questions/29957
**Category:** User Support
**Created:** [April 17, 2024, 3:06pm UTC](https://forum.qiime2.org/t/ancombc-clarifying-questions/29957 "2024-04-17T15:06:27Z")
**Posts on this page:** 1
**Showing post:** 2

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### Author: ![timanix](https://forum.qiime2.org/user_avatar/forum.qiime2.org/timanix/32/17879_2.png) [@timanix](https://forum.qiime2.org/u/timanix)
#### Post date: [April 17, 2024, 3:41pm UTC](https://forum.qiime2.org/t/ancombc-clarifying-questions/29957/2 "2024-04-17T15:41:57Z")

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Hello and Welcome to the forum!

Unfortunately, pairwise comparisons are not implemented in Qiime2. You can provide the reference and compare all the groups to that reference. Also, I don't think that it is appropriate to perform multiple runs and then just correct p-values (I had the same idea).

Please check this [comment](https://forum.qiime2.org/t/question-about-ancom-bc2/29878/5). By the link there you can find detailed R tutorial for ancombc2, including pairwise mode.

Best,

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