ANCOM abundance table: more abundant in which treatment?

[colinbrislawn (Colin J Brislawn)]

Hello Lindsay,

I'm a little out of my depth as I'm not a statistician, but let's start with the CLR statistic.

I googled CLR and it turns up CLR® Calcium, Lime, & Rust Remover, which is not a stat test

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In our context, CLR stands for center log ratio, which works like this :

@mortonjt

clr coordinate do not necessarily imply increase / decrease (since it is not possible do this in the first place). Instead, these coordinates represent log-fold change relative to the average microbe.

This paper goes into more of the math, and explains why CLR is helpful for samples with different numbers of reads.

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@xchromosome

So from what I can gather, it seems like features appearing in the top left of the graph are just as significant/valid/important as those in the top right, in this case where there are only two groups? Is that correct?

Yep! That sounds correct to me. These microbes are decreasing between groups.

EDIT: I don't have any idea what I'm talking about. I think a statistician needs to 'qiime-in' to tell you how best to report this.

Colin